1,2-di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate
di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate
CAS: 91229-91-3
Molecular Formula: C14H23NO5
1,2-di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate - Names and Identifiers
1,2-di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate - Physico-chemical Properties
| Molecular Formula | C14H23NO5 |
| Molar Mass | 285.34 |
| Density | 1.138±0.06 g/cm3(Predicted) |
| Melting Point | 55.0 to 59.0 °C |
| Boling Point | 390.7±35.0 °C(Predicted) |
| Flash Point | 190.067°C |
| Vapor Presure | 0mmHg at 25°C |
| pKa | -4.28±0.40(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.485 |
1,2-di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate - Introduction
di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate is a compound whose chemical formula is C14H23NO6. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate is a colorless to white crystalline solid.
-Solubility: It is soluble in organic solvents such as ethanol, methanol and dimethyl sulfoxide.
-Melting point: The compound melts at about 104-105°C.
Use:
di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate is a commonly used amino acid derivative, often used as a reagent in organic synthesis. It can be used to synthesize biologically active compounds, such as drugs and polymer materials.
Method:
The preparation of di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate is usually carried out by the following steps:
1. Dissolve pyroglutamic acid tert-butyl ester in dry dimethyl sulfoxide.
2. An appropriate amount of N,N'-dihydroxyethyl isopropanamide was added and the reaction mixture was cooled to below 0°C.
3. Add di-tert-butyl carbonate slowly while maintaining the temperature of the reaction mixture below 0°C.
4. After completion of the reaction, the reaction mixture was added to water to produce a solid precipitate of di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate.
5. The final product was obtained by the steps of crystallization, filtration and drying.
Safety Information:
di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate should be used and handled in accordance with safe practices to avoid exposure to skin, eyes and inhalation. In addition, it should be stored in a dry, cool place and away from fire and oxidants. For specific safety information, refer to the Chemical Safety Data Sheet (MSDS) or the relevant information provided by the supplier.
Nature:
-Appearance: di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate is a colorless to white crystalline solid.
-Solubility: It is soluble in organic solvents such as ethanol, methanol and dimethyl sulfoxide.
-Melting point: The compound melts at about 104-105°C.
Use:
di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate is a commonly used amino acid derivative, often used as a reagent in organic synthesis. It can be used to synthesize biologically active compounds, such as drugs and polymer materials.
Method:
The preparation of di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate is usually carried out by the following steps:
1. Dissolve pyroglutamic acid tert-butyl ester in dry dimethyl sulfoxide.
2. An appropriate amount of N,N'-dihydroxyethyl isopropanamide was added and the reaction mixture was cooled to below 0°C.
3. Add di-tert-butyl carbonate slowly while maintaining the temperature of the reaction mixture below 0°C.
4. After completion of the reaction, the reaction mixture was added to water to produce a solid precipitate of di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate.
5. The final product was obtained by the steps of crystallization, filtration and drying.
Safety Information:
di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate should be used and handled in accordance with safe practices to avoid exposure to skin, eyes and inhalation. In addition, it should be stored in a dry, cool place and away from fire and oxidants. For specific safety information, refer to the Chemical Safety Data Sheet (MSDS) or the relevant information provided by the supplier.
Last Update：2024-04-09 20:52:54
Supplier List
Product Name: (S)-N-ALPHA-T-BUTYLOXYCARBONYL-PYROGLUTAMIC ACID T-BUTYL ESTER Visit Supplier Webpage Request for quotation
CAS: 91229-91-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 91229-91-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: (S)-N-ALPHA-T-BUTYLOXYCARBONYL-PYROGLUTAMIC ACID T-BUTYL ESTER Visit Supplier Webpage Request for quotation
CAS: 91229-91-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 91229-91-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History